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Paxalisib (GDC-0084)

Product Specifications

CAS Number

1382979-44-3

Synonyms

RG7666

Target

PI3K

Applications

PI3K/Akt/mTOR

Smiles

CC1 (C2=NC3=C (N2CCO1) N=C (N=C3N4CCOCC4) C5=CN=C (N=C5) N) C

Molecular Formula

C18H22N8O2

Additionnal Information

Paxalisib (GDC-0084, RG7666) is a brain penetrant inhibitor of PI3K and mTOR with Kiapp values of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.

Storage Conditions

2 years -80 in solvent

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