Plicamycin

CC1C (C (CC (O1) OC2CC (OC (C2O) C) OC3=CC4=CC5=C (C (=O) C (C (C5) C (C (=O) C (C (C) O) O) OC) OC6CC (C (C (O6) C) O) OC7CC (C (C (O7) C) O) OC8CC (C (C (O8) C) O) (C) O) C (=C4C (=C3C) O) O) O) O

Plicamycin (Mithramycin A) a selective inhibitor of Sp1, is a natural polycyclic aromatic polyketide isolated from Streptomyces strains. It binds to GC-rich DNA sequences, displacing Sp1 transcription factor from oncogene promoters, inhibiting their expression, with anti-tumor and neuroprotective effects.