Sivelestat

127373-66-4

ONO-5046, LY544349, EI546

Serine Protease

Proteases

CC (C) (C) C (=O) OC1=CC=C (C=C1) S (=O) (=O) NC2=CC=CC=C2C (=O) NCC (=O) O

C20H22N2O7S

Sivelestat is a potent and selective inhibitor of neutrophil elastase with IC50 of 44nM. It almost shows no activity at a range of other proteases.

2 years -80 in solvent