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GANT61

Product Specifications

CAS Number

500579-04-4

Synonyms

NSC 136476

Target

Hedgehog/Smoothened

Applications

Stem Cells & Wnt

Smiles

CN (C) C1=CC=CC=C1CN2CCCN (C2C3=CC=NC=C3) CC4=CC=CC=C4N (C) C

Molecular Formula

C27H35N5

Additionnal Information

GANT61 (NSC 136476) is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM in GLI1 expressing HEK293T cell, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation. GANT61 induces apoptosis and activates protective autophagy in LX-2 cells.

Storage Conditions

2 years -80 in solvent

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