Nutlin-3a
Product Specifications
CAS Number
675576-98-4
Synonyms
(-) -Nutlin-3
Target
MDM2/MDMX
Applications
Apoptosis
Smiles
CC (C) OC1=C (C=CC (=C1) OC) C2=NC (C (N2C (=O) N3CCNC (=O) C3) C4=CC=C (C=C4) Cl) C5=CC=C (C=C5) Cl
Molecular Formula
C30H30Cl2N4O4
Additionnal Information
Nutlin-3a ((-) -Nutlin-3), the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay. Nutlin-3a induces autophagy and apoptosis in a p53-dependent manner.
Storage Conditions
2 years -80 in solvent
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