Venetoclax (ABT-199)
Product Specifications
CAS Number
1257044-40-8
Synonyms
GDC-0199
Target
Bcl-2
Applications
Apoptosis
Smiles
CC1 (CCC (=C (C1) C2=CC=C (C=C2) Cl) CN3CCN (CC3) C4=CC (=C (C=C4) C (=O) NS (=O) (=O) C5=CC (=C (C=C5) NCC6CCOCC6) [N+] (=O) [O-]) OC7=CN=C8C (=C7) C=CN8) C
Molecular Formula
C45H50ClN7O7S
Additionnal Information
Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Venetoclax is reported to induce cell growth suppression, apoptosis, cell cycle arrest, and autophagy in triple negative breast cancer MDA-MB-231 cells. Phase 3.
Storage Conditions
2 years -80 in solvent
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