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VE-821

Product Specifications

CAS Number

1232410-49-9

Synonyms

ATR inhibitor IV

Target

ATM/ATR

Applications

PI3K/Akt/mTOR

Smiles

CS (=O) (=O) C1=CC=C (C=C1) C2=CN=C (C (=N2) C (=O) NC3=CC=CC=C3) N

Molecular Formula

C18H16N4O3S

Additionnal Information

VE-821 (ATR inhibitor IV) is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM in cell-free assays, shows inhibition of H2AX phosphorylation, minimal activity against PIKKs ATM, DNA-PK, mTOR and PI3Kγ.

Storage Conditions

2 years -80 in solvent

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