BIX-01294 trihydrochloride
Product Specifications
CAS Number
1392399-03-9
Target
Histone Methyltransferase
Applications
Epigenetics
Smiles
CN1CCCN (CC1) C2=NC3=CC (=C (C=C3C (=N2) NC4CCN (CC4) CC5=CC=CC=C5) OC) OC.Cl.Cl.Cl
Molecular Formula
C28H38N6O2.3HCl
Additionnal Information
BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM in a cell-free assay, reduces H3K9me2 of bulk histones, also weakly inhibits GLP (primarily H3K9me3), no significant activity observed at other histone methyltransferases. BIX01294 induces autophagy. BIX01294 also inhibits H3K36 methylation by oncoproteins NSD1, NSD2 and NSD3.
Storage Conditions
2 years -80 in solvent
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