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Bioymifi

Product Specifications

CAS Number

1420071-30-2

Target

TNF-alpha

Applications

Apoptosis

Smiles

C1=CC (=CC=C1N2C (=O) C (=CC3=CC=C (O3) C4=CC5=C (C=C4) C (=O) NC5=O) SC2=N) Br

Molecular Formula

C22H12BrN3O4S

Additionnal Information

Bioymifi, a small-molecule death receptor 5 (DR5) agonist, binds to the extracellular domain (ECD) of DR5 with a Kd of 1.2 μM but showed little binding affinity to the DR4 ECD. It induces DR5 clustering and aggregation, leading to apoptosis.

Storage Conditions

2 years -80 in solvent

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