Lifirafenib (BGB-283)
Product Specifications
CAS Number
1446090-79-4
Synonyms
Beigene-283
Target
Raf
Applications
MAPK
Smiles
C1CC (=O) NC2=NC=CC (=C21) OC3=CC4=C (C=C3) OC5C4C5C6=NC7=C (N6) C=C (C=C7) C (F) (F) F
Molecular Formula
C25H17F3N4O3
Additionnal Information
Lifirafenib (BGB-283, Beigene-283) potently inhibits RAF family kinases and EGFR activities in biochemical assays with IC50 values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant.
Storage Conditions
2 years -80 in solvent
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