Thapsigargin
Product Specifications
CAS Number
67526-95-8
Target
ATPase
Applications
Transmembrane Transporters
Smiles
CCCCCCCC (=O) OC1C2C (=C (C1OC (=O) C (=CC) C) C) C3C (C (CC2 (C) OC (=O) C) OC (=O) CCC) (C (C (=O) O3) (C) O) O
Molecular Formula
C34H50O12
Additionnal Information
Thapsigargin is a potent, non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50 of 0.353 nM or 0.448 nM for the carbachol-evoked [Ca2+]i-transients with or without a KCl-prestimulation. Thapsigargin induces cell apoptosis. Thapsigargin is extracted from a plant, Thapsia garganica.
Storage Conditions
3 years -20°C powder
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