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Thapsigargin

Product Specifications

CAS Number

67526-95-8

Target

ATPase

Applications

Transmembrane Transporters

Smiles

CCCCCCCC (=O) OC1C2C (=C (C1OC (=O) C (=CC) C) C) C3C (C (CC2 (C) OC (=O) C) OC (=O) CCC) (C (C (=O) O3) (C) O) O

Molecular Formula

C34H50O12

Additionnal Information

Thapsigargin is a potent, non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50 of 0.353 nM or 0.448 nM for the carbachol-evoked [Ca2+]i-transients with or without a KCl-prestimulation. Thapsigargin induces cell apoptosis. Thapsigargin is extracted from a plant, Thapsia garganica.

Storage Conditions

3 years -20°C powder

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