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Rottlerin

Product Specifications

CAS Number

82-08-6

Synonyms

Mallotoxin, NSC 56346, NSC 94525

Target

PKC

Applications

Cytoskeletal Signaling

Smiles

CC1=C (C (=C (C (=C1O) C (=O) C) O) CC2=C (C (=C3C (=C2O) C=CC (O3) (C) C) C (=O) C=CC4=CC=CC=C4) O) O

Molecular Formula

C30H28O8

Additionnal Information

Rottlerin (Mallotoxin, NSC 56346, NSC 94525), a natural compound purified from Mallotus Philippinensis, is a specific Protein kinase inhibitor with IC50 of 3 μM, 6 μM and 5.3 μM for PKCδ (from baculovirus-infected Sf9 insect cells), PKCδ (from porcine spleen) and CaM kinase III, respectively. Rottlerin also inhibits PKCα, PKCγ, PKCβ, PKCη, CKII and PKA with IC50 of 30 μM, 40 μM, 42 μM, 82 μM, 30 μM and 78 μM, respectively.

Storage Conditions

3 years -20°C powder

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