Pexidartinib (PLX3397)
Product Specifications
CAS Number
1029044-16-3
Target
CSF-1R
Applications
Protein Tyrosine Kinase
Smiles
C1=CC (=NC=C1CC2=CNC3=C2C=C (C=N3) Cl) NCC4=CN=C (C=C4) C (F) (F) F
Molecular Formula
C20H15ClF3N5
Additionnal Information
Pexidartinib (PLX3397) is an oral, potent multi-targeted receptor tyrosine kinase inhibitor of CSF-1R, Kit (c-Kit), and FLT3 with IC50 of 20 nM, 10 nM and 160 nM, respectively. Pexidartinib (PLX3397) induces apoptosis and necrosis with antitumor activity. Phase 3.
Storage Conditions
2 years -80 in solvent
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