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MI-503

Product Specifications

CAS Number

1857417-13-0

Target

Histone Methyltransferase

Applications

Epigenetics

Smiles

CC1=C (C=CC2=C1C=C (N2CC3=CNN=C3) C#N) CN4CCC (CC4) NC5=C6C=C (SC6=NC=N5) CC (F) (F) F

Molecular Formula

C28H27F3N8S

Additionnal Information

MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines (GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations.

Storage Conditions

2 years -80 in solvent

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