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Purvalanol A

Product Specifications

CAS Number

212844-53-6

Target

CDK

Applications

Cell Cycle

Smiles

CC (C) C (CO) NC1=NC (=C2C (=N1) N (C=N2) C (C) C) NC3=CC (=CC=C3) Cl

Molecular Formula

C19H25ClN6O

Additionnal Information

Purvalanol A is a potent, and cell-permeable CDK inhibitor with IC50 of 4 nM, 70 nM, 35 nM, and 850 nM for cdc2-cyclin B, cdk2-cyclin A, cdk2-cyclin E, and cdk4-cyclin D1, respectively. Purvalanol A induces endoplasmic reticulum stress-mediated apoptosis and autophagy.

Storage Conditions

2 years -80 in solvent

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