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Sunitinib

Product Specifications

CAS Number

557795-19-4

Synonyms

SU11248

Target

PDGFR

Applications

Protein Tyrosine Kinase

Smiles

CCN (CC) CCNC (=O) C1=C (NC (=C1C) C=C2C3=C (C=CC (=C3) F) NC2=O) C

Molecular Formula

C22H27FN4O2

Additionnal Information

Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.

Storage Conditions

2 years -80 in solvent

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