Pimitespib (TAS-116)
Product Specifications
CAS Number
1260533-36-5
Target
HSP (HSP90)
Applications
Cytoskeletal Signaling
Smiles
CCC1=C (C=CC (=C1) C (=O) N) N2C3=NC=CC (=C3C (=N2) C (C) C) N4C=C (N=C4) C5=CN (N=C5) C
Molecular Formula
C25H26N8O
Additionnal Information
Pimitespib (TAS-116) is a novel, small-molecule HSP90 inhibitor which inhibits geldanamycin-FITC binding to HSP90 proteins with Ki values of 34.7 nmol/L, 21.3 nmol/L, >50,000 nmol/L, and >50,000 nmol/L for HSP90α, HSP90β, GRP94, and TRAP1, respectively. Furthermore, TAS-116 does not inhibit other ATPases such as HSP70 (IC50 >200 μmol/L) .
Storage Conditions
3 years -20°C powder
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