Ki20227
Product Specifications
CAS Number
623142-96-1
Target
CSF-1R
Applications
Protein Tyrosine Kinase
Smiles
CC (C1=NC=CS1) NC (=O) NC2=C (C=C (C=C2) OC3=C4C=C (C (=CC4=NC=C3) OC) OC) OC
Molecular Formula
C24H24N4O5S
Additionnal Information
Ki20227 is an orally active and highly selective inhibitor of c-Fms tyrosine kinase (CSF1R) with IC50 of 2 nM, 12 nM, 451 nM and 217 nM for c-Fms, vascular endothelial growth factor receptor-2 (KDR/VEGFR-2), stem cell factor receptor (c-Kit), and platelet-derived growth factor receptor beta (PDGFRβ), respectively.
Storage Conditions
3 years -20°C powder
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