SAR405
Product Specifications
CAS Number
1523406-39-4
Target
PI3K
Applications
PI3K/Akt/mTOR
Smiles
CC1COCCN1C2=CC (=O) N3CCC (N (C3=N2) CC4=CC (=CN=C4) Cl) C (F) (F) F
Molecular Formula
C19H21ClF3N5O2
Additionnal Information
SAR405 is a low-molecular-mass kinase inhibitor of PIK3C3/Vps34 (KD 1.5 nM) showing high selectivity and not be active up to 10 μM on class I and class II PI3Ks as well as on mTOR. SAR405 prevents autophagy and synergizes with MTOR (mechanistic target of rapamycin) inhibition in tumor cells.
Storage Conditions
2 years -80 in solvent
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