Picropodophyllin (PPP)
Product Specifications
CAS Number
477-47-4
Synonyms
AXL1717
Target
IGF-1R
Applications
Protein Tyrosine Kinase
Smiles
COC1=CC (=CC (=C1OC) OC) C2C3C (COC3=O) C (C4=CC5=C (C=C24) OCO5) O
Molecular Formula
C22H22O8
Additionnal Information
Picropodophyllin (PPP, AXL1717) is a IGF-1R inhibitor with IC50 of 1 nM. It displays selectivity for IGF-1R and does not coinhibit tyrosine phosphorylation the IR, or of a selected panel of receptors less related to IGF-IR (FGF-R, PDGF-R, OR EGF-R) . Picropodophyllin (PPP) induces apoptosis with antineoplastic activity.
Storage Conditions
2 years -80 in solvent
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