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D 4476

Product Specifications

CAS Number

301836-43-1

Target

Casein Kinase

Applications

Cell Cycle

Smiles

C1COC2=C (O1) C=CC (=C2) C3=C (NC (=N3) C4=CC=C (C=C4) C (=O) N) C5=CC=CC=N5

Molecular Formula

C23H18N4O3

Additionnal Information

D 4476 is a potent, selective, and cell-permeant CK1 (casein kinase 1) inhibitor with IC50 of 200 nM and 300 nM in a cell-free assay for CK1 from Schizosaccharomyces pombe and CK1δ, respectively. Also acts as an ALK5 inhibitor with IC50 of 500 nM.

Storage Conditions

2 years -80 in solvent

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