D 4476
Product Specifications
CAS Number
301836-43-1
Target
Casein Kinase
Applications
Cell Cycle
Smiles
C1COC2=C (O1) C=CC (=C2) C3=C (NC (=N3) C4=CC=C (C=C4) C (=O) N) C5=CC=CC=N5
Molecular Formula
C23H18N4O3
Additionnal Information
D 4476 is a potent, selective, and cell-permeant CK1 (casein kinase 1) inhibitor with IC50 of 200 nM and 300 nM in a cell-free assay for CK1 from Schizosaccharomyces pombe and CK1δ, respectively. Also acts as an ALK5 inhibitor with IC50 of 500 nM.
Storage Conditions
2 years -80 in solvent
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