CPI-169

1450655-76-1

Histone Methyltransferase

Epigenetics

CCS (=O) (=O) N1CCC (CC1) C (C) N2C (=C (C3=CC=CC=C32) C (=O) NCC4=C (C=C (NC4=O) C) OC) C

C27H36N4O5S

CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.

2 years -80 in solvent