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Piperlongumine

Product Specifications

CAS Number

20069-09-4

Synonyms

PPLGM, Piplartine

Target

ROS

Applications

NF-κB

Smiles

COC1=CC (=CC (=C1OC) OC) C=CC (=O) N2CCC=CC2=O

Molecular Formula

C17H19NO5

Additionnal Information

Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.

Storage Conditions

2 years -80 in solvent

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