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Resatorvid (TAK-242)

Product Specifications

CAS Number

243984-11-4

Synonyms

CLI-095

Target

TLR

Applications

Immunology & Inflammation

Smiles

CCOC (=O) C1=CCCCC1S (=O) (=O) NC2=C (C=C (C=C2) F) Cl

Molecular Formula

C15H17ClFNO4S

Additionnal Information

Resatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy.

Storage Conditions

3 years -20°C powder

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