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Rocaglamide

Product Specifications

CAS Number

84573-16-0

Synonyms

Roc-A

Target

HSP (HSP90)

Applications

Cytoskeletal Signaling

Smiles

CN (C) C (=O) C1C (C2 (C (C1O) (C3=C (O2) C=C (C=C3OC) OC) O) C4=CC=C (C=C4) OC) C5=CC=CC=C5

Molecular Formula

C29H31NO7

Additionnal Information

Rocaglamide (Roc-A), isolated from Aglaia species, is a potent inhibitor of heat shock factor 1 (HSF1) activation with IC50 of ~50 nM for HSF1. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also inhibits NF-κB activity. Rocaglamide exhibits anti-tumor activity.

Storage Conditions

3 years -20°C powder

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