KN-62
Product Specifications
CAS Number
127191-97-3
Target
CaMK
Applications
Neuronal Signaling
Smiles
CN (C (CC1=CC=C (C=C1) OS (=O) (=O) C2=CC=CC3=C2C=CN=C3) C (=O) N4CCN (CC4) C5=CC=CC=C5) S (=O) (=O) C6=CC=CC7=C6C=CN=C7
Molecular Formula
C38H35N5O6S2
Additionnal Information
KN-62 is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.9 μM; also a non-competitive antagonist of the purinergic receptor P2RX7 (IC50 = 15 nM) . It is selective for CaMKII relative to PKA, PKC and MLCK, but inhibits CaMKI and CaMKIV equally well, The Ki value of KN-62 for CaMK V is 0.8 μM.
Storage Conditions
2 years -80 in solvent
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