Sorafenib
Product Specifications
CAS Number
284461-73-0
Synonyms
NSC-724772, BAY 43-9006
Target
Raf
Applications
MAPK
Smiles
CNC (=O) C1=NC=CC (=C1) OC2=CC=C (C=C2) NC (=O) NC3=CC (=C (C=C3) Cl) C (F) (F) F
Molecular Formula
C21H16ClF3N4O3
Additionnal Information
Sorafenib is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.
Storage Conditions
2 years -80 in solvent
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