EPZ004777

Product Specifications

CAS Number

1338466-77-5

Target

Histone Methyltransferase

Applications

Epigenetics

Smiles

CC (C) N (CCCNC (=O) NC1=CC=C (C=C1) C (C) (C) C) CC2C (C (C (O2) N3C=CC4=C (N=CN=C43) N) O) O

Molecular Formula

C28H41N7O4

Additionnal Information

EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM in a cell-free assay and demonstrates >1,200-fold selectivity for DOT1L over all other tested PMTs. EPZ004777 induces apoptosis.

Storage Conditions

2 years -80 in solvent

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