AZ5104
Product Specifications
CAS Number
1421373-98-9
Target
EGFR
Applications
Protein Tyrosine Kinase
Smiles
CN (C) CCN (C) C1=CC (=C (C=C1NC (=O) C=C) NC2=NC=CC (=N2) C3=CNC4=CC=CC=C43) OC
Molecular Formula
C27H31N7O2
Additionnal Information
AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.
Storage Conditions
2 years -80 in solvent
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