Rociletinib (CO-1686)
Product Specifications
CAS Number
1374640-70-6
Synonyms
AVL-301
Target
EGFR
Applications
Protein Tyrosine Kinase
Smiles
CC (=O) N1CCN (CC1) C2=CC (=C (C=C2) NC3=NC=C (C (=N3) NC4=CC (=CC=C4) NC (=O) C=C) C (F) (F) F) OC
Molecular Formula
C27H28F3N7O3
Additionnal Information
Rociletinib (CO-1686, AVL-301) is an irreversible, mutant-selective EGFR inhibitor with Ki of 21.5 nM and 303.3 nM for EGFRL858R/T790M and EGFRWT in cell-free assays, respectively. Phase 2.
Storage Conditions
2 years -80 in solvent
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