Onvansertib (NMS-P937)
Product Specifications
CAS Number
1034616-18-6
Synonyms
PCM-075, NMS1286937
Target
PLK
Applications
Cell Cycle
Smiles
CN1CCN (CC1) C2=CC (=C (C=C2) OC (F) (F) F) NC3=NC=C4CCC5=C (C4=N3) N (N=C5C (=O) N) CCO
Molecular Formula
C24H27F3N8O3
Additionnal Information
Onvansertib (NMS-P937, PCM-075, NMS1286937) is an orally available, selective Polo-like Kinase 1 (PLK1) inhibitor with IC50 of 2 nM, 5000-fold selectivity over PLK2/PLK3. Onvansertib (NMS-P937) potently causes a mitotic cell-cycle arrest followed by apoptosis in cancer cell lines and inhibits tumor growth. Phase 1.
Storage Conditions
2 years -80 in solvent
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