Alvelestat (AZD9668)
Product Specifications
CAS Number
848141-11-7
Synonyms
Avelestat
Target
Serine Protease
Applications
Proteases
Smiles
CC1=C (C=C (C (=O) N1C2=CC=CC (=C2) C (F) (F) F) C (=O) NCC3=NC=C (C=C3) S (=O) (=O) C) C4=CC=NN4C
Molecular Formula
C25H22F3N5O4S
Additionnal Information
Alvelestat (AZD9668, Avelestat) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases. Phase 2.
Storage Conditions
2 years -80 in solvent
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