Bisindolylmaleimide IX (Ro 31-8220) Mesylate
Product Specifications
CAS Number
138489-18-6
Target
PKC
Applications
Cytoskeletal Signaling
Smiles
CN1C=C (C2=CC=CC=C21) C3=C (C (=O) NC3=O) C4=CN (C5=CC=CC=C54) CCCSC (=N) N.CS (=O) (=O) O
Molecular Formula
C25H23N5O2S.CH4O3S
Additionnal Information
Bisindolylmaleimide IX (Ro 31-8220 Mesylate) is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively, and also shows potent inhibition against MAPKAP-K1b, MSK1, GSK3β and S6K1.
Storage Conditions
2 years -80 in solvent
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