Fosbretabulin (Combretastatin A4 Phosphate) Disodium
Product Specifications
CAS Number
168555-66-6
Synonyms
CA 4DP
Target
Microtubule Associated
Applications
Cytoskeletal Signaling
Smiles
COC1=C (C=C (C=C1) C=CC2=CC (=C (C (=C2) OC) OC) OC) OP (=O) ([O-]) [O-].[Na+].[Na+]
Molecular Formula
C18H19O8P.2Na
Additionnal Information
Fosbretabulin (Combretastatin A4 Phosphate) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Fosbretabulin disodium induces mitotic arrest and apoptosis in endothelial cells. Phase 3.
Storage Conditions
2 years -80 in solvent
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