Avutometinib

Product Specifications

CAS Number

946128-88-7

Synonyms

RO5126766, CH5126766, VS 6766, CKI-27, R-7304, RG-7304

Target

Raf

Applications

MAPK

Smiles

CC1=C (C (=O) OC2=C1C=CC (=C2) OC3=NC=CC=N3) CC4=C (C (=NC=C4) NS (=O) (=O) NC) F

Molecular Formula

C21H18FN5O5S

Additionnal Information

Avutometinib (RO5126766, CH5126766, VS 6766, CKI-27, R-7304, RG-7304) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM,19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.

Storage Conditions

2 years -80 in solvent

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