UNC1999
Product Specifications
CAS Number
1431612-23-5
Target
Histone Methyltransferase
Applications
Epigenetics
Smiles
CCCC1=C (C (=O) NC (=C1) C) CNC (=O) C2=C3C=NN (C3=CC (=C2) C4=CN=C (C=C4) N5CCN (CC5) C (C) C) C (C) C
Molecular Formula
C33H43N7O2
Additionnal Information
UNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays, respectively, showing >1000-fold selectivity over a broad range of epigenetic and non-epigenetic targets. UNC1999 is a potent autophagy inducer. UNC1999 specifically suppresses H3K27me3/2 and induces a range of anti-leukemia effects including anti-proliferation, differentiation, and apoptosis.
Storage Conditions
2 years -80 in solvent
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