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GSK923295

Product Specifications

CAS Number

1088965-37-0

Target

Kinesin

Applications

Cytoskeletal Signaling

Smiles

CC (C) OC1=C (C=C (C=C1) C (=O) NC (CC2=CC=C (C=C2) C3=CN4C=CC=C (C4=N3) C (C) O) CNC (=O) CN (C) C) Cl

Molecular Formula

C32H38ClN5O4

Additionnal Information

GSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with Ki of 3.2 nM, and less potent to mutant I182 and T183. GSK923295 induces post-mitotic apoptosis. Phase 1.

Storage Conditions

2 years -80 in solvent

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