Pinometostat (EPZ5676)
Product Specifications
CAS Number
1380288-87-8
Target
Histone Methyltransferase
Applications
Epigenetics
Smiles
CC (C) N (CC1C (C (C (O1) N2C=NC3=C (N=CN=C32) N) O) O) C4CC (C4) CCC5=NC6=C (N5) C=C (C=C6) C (C) (C) C
Molecular Formula
C30H42N8O3
Additionnal Information
Pinometostat (EPZ5676) is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM in a cell-free assay, demonstrating >37,000-fold selectivity against all other PMTs tested, inhibits H3K79 methylation in tumor. Phase 1.
Storage Conditions
2 years -80 in solvent
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