LY2874455

Product Specifications

CAS Number

1254473-64-7

Target

FGFR

Applications

Protein Tyrosine Kinase

Smiles

CC (C1=C (C=NC=C1Cl) Cl) OC2=CC3=C (C=C2) NN=C3C=CC4=CN (N=C4) CCO

Molecular Formula

C21H19Cl2N5O2

Additionnal Information

LY2874455 is a pan-FGFR inhibitor with IC50 of 2.8 nM, 2.6 nM, 6.4 nM, and 6 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively, and also inhibits VEGFR2 activity with IC50 of 7 nM. Phase 1.

Storage Conditions

2 years -80 in solvent

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