GSK2656157
Product Specifications
CAS Number
1337532-29-2
Target
PERK
Applications
Apoptosis
Smiles
CC1=NC (=CC=C1) CC (=O) N2CCC3=C2C=CC (=C3F) C4=CN (C5=NC=NC (=C45) N) C
Molecular Formula
C23H21FN6O
Additionnal Information
GSK2656157 is an ATP-competitive and highly selective inhibitor of PERK with IC50 of 0.9 nM in a cell-free assay, 500-fold greater against a panel of 300 kinases. GSK2656157 decreases apoptosis and inhibits excessive autophagy.
Storage Conditions
2 years -80 in solvent
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