Merestinib (LY2801653)
Product Specifications
CAS Number
1206799-15-6
Target
C-Met
Applications
Protein Tyrosine Kinase
Smiles
CC1=CC=C (C (=O) N1C2=CC=C (C=C2) F) C (=O) NC3=CC (=C (C=C3) OC4=C (C=C5C (=C4) C=NN5C) C6=CNN=C6) F
Molecular Formula
C30H22F2N6O3
Additionnal Information
Merestinib (LY2801653) is a type-II ATP competitive, slow-off inhibitor of Met (c-Met) tyrosine kinase with a dissociation constant (Ki) of 2 nM, a pharmacodynamic residence time (Koff) of 0.00132 min (-1) and t1/2 of 525 min. Merestinib (LY2801653) also inhibits MST1R, AXL, ROS1, MKNK1/2, FLT3, MERTK, DDR1 and DDR2 with IC50 of 11 nM, 2 nM, 23 nM, 7 nM, 7 nM, 10 nM, 0.1 nM and 7 nM, respectively.
Storage Conditions
2 years -80 in solvent
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
123727-PE 100 µL
ATP6V1C1 (V-type Proton ATPase Subunit C 1, V-ATPase Subunit C 1, Vacuolar Proton Pump Subunit C 1, ATP6C, ATP6D, VATC) (PE)
Sign In for Pricing
View Details 
MBS6192948-01 0.1 mL
Synapsin I (Synapsin 1, Synapsin-1, SYN1, SYN-1, Synapsin-I, SYNI, SYN-I, Brain Protein 4.1) (MaxLight 405)
Sign In for Pricing
View Details MBS6192948-02 5x 0.1 mL
Synapsin I (Synapsin 1, Synapsin-1, SYN1, SYN-1, Synapsin-I, SYNI, SYN-I, Brain Protein 4.1) (MaxLight 405)
Sign In for Pricing
View Details C1105-80H 200 µL
CA9, ID (Carbonic Anhydrase 9, Carbonic Anhydrase IX, Carbonate Dehydratase IX, CA-IX, CAIX, Membrane Antigen MN, P54/58N, Renal Cell Carcinoma-associated Antigen G250, RCC-associated Antigen G250, pMW1, G250, MN)
Sign In for Pricing
View Details APRab06229-01 20 µL
NF-E4 (Acetyl Lys43) Rabbit Polyclonal Antibody
Sign In for Pricing
View Details