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Binimetinib (MEK162)

Product Specifications

CAS Number

606143-89-9

Synonyms

ARRY-162, ARRY-438162

Target

MEK

Applications

Protein Tyrosine Kinase

Smiles

CN1C=NC2=C1C=C (C (=C2F) NC3=C (C=C (C=C3) Br) F) C (=O) NOCCO

Molecular Formula

C17H15BrF2N4O3

Additionnal Information

Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Binimetinib induces G1 cell cycle arrest and apoptosis in human NSCLC cell lines and induces autophagy. Phase 3.

Storage Conditions

2 years -80 in solvent

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