LC-2
Product Specifications
CAS Number
2502156-03-6
Synonyms
PROTAC KRASG12C Degrader-LC-2
Target
Ras
Applications
Apoptosis
Molecular Formula
C59H71ClFN11O7S
Additionnal Information
LC-2 is a first PROTAC capable of degrading endogenous KRASG12C with DC50s between 0.25 μM and 0.76 μM. LC-2 covalently binds KRASG12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling.
Storage Conditions
3 years -20°C powder
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6142518-01 0.1 mL
ITGA1 (Integrin alpha-1, Integrin, alpha 1, CD49 Antigen-like Family Member A, CD49a, CD49a Antigen, Laminin and Collagen Receptor, Very Late Activation Protein 1, VLA1, VLA-1) (Biotin)
Sign In for Pricing
View Details MBS6142518-02 5x 0.1 mL
ITGA1 (Integrin alpha-1, Integrin, alpha 1, CD49 Antigen-like Family Member A, CD49a, CD49a Antigen, Laminin and Collagen Receptor, Very Late Activation Protein 1, VLA1, VLA-1) (Biotin)
Sign In for Pricing
View Details 