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GW406108X

Product Specifications

CAS Number

1644443-92-4

Synonyms

GW108X

Target

Kinesin

Applications

Cytoskeletal Signaling

Smiles

OC1=C (Cl) C=C (C=C1Cl) /C=C/2C (=O) NC3=C2C=C (C=C3) C (=O) C4=CC=CO4

Molecular Formula

C20H11Cl2NO4

Additionnal Information

GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.

Storage Conditions

3 years -20°C powder

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