AMG-9810
Product Specifications
CAS Number
545395-94-6
Target
TRP Channel
Applications
Neuronal Signaling
Smiles
CC (C) (C) C1=CC=C (/C=C/C (=O) NC2=CC=C3OCCOC3=C2) C=C1
Molecular Formula
C21H23NO3
Additionnal Information
AMG-9810 is a potent, competitive and selective vanilloid receptor 1 (TRPV1) antagonist and inhibits capsaicin activation with IC50 of 24.5 nM and 85.6 nM for human TRPV1 and rat TRPV1, repectively. AMG-9810 blocks all known modes of TRPV1 activation, including protons-, heat-, and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. AMG-9810 significantly reduces the mRNA expression of TLR2 and TLR4. AMG-9810 also promotes mouse skin tumorigenesis mediated through EGFR/Akt/mTOR signaling.
Storage Conditions
3 years -20°C powder
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