What is the catalog number for NE 52-QQ57?

The catalog number for NE 52-QQ57 is S6850-25mg.

What sizes are available for NE 52-QQ57?

NE 52-QQ57 is available in the following size(s): 25 mg.

Is NE 52-QQ57 in stock?

NE 52-QQ57 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures NE 52-QQ57?

NE 52-QQ57 is manufactured by Bimake.

What is the estimated delivery time for NE 52-QQ57?

Estimated delivery time for NE 52-QQ57 is approximately 15 business day(s), depending on your location.

NE 52-QQ57

Product Specifications

CAS Number

1401728-56-0

Target

GPR

Applications

GPCR & G Protein

Smiles

CCC1=NN2C (=CC (=NC2=C1CC3=CC=C (C=C3) C4=NN=C (O4) C5CCNCC5) C) C

Molecular Formula

C24H28N6O

Additionnal Information

NE 52-QQ57 is a selective, and orally available antagonist of G-protein coupled receptor 4 (GPR4) with IC50 of 0.07 μM. NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26.8 nM in HEK293 cells. The antagonism of GPR4 with NE 52-QQ57 significantly inhibits the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL) -1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2) .