RU.521

Product Specifications

CAS Number

2262452-06-0

Synonyms

RU320521

Target

CGAS

Applications

Autophagy

Smiles

CC1=C (C (=O) N (N1) C2=NC3=C (N2) C=CC (=C3Cl) Cl) C4C5=CC=CC=C5C (=O) O4

Molecular Formula

C19H12Cl2N4O3

Additionnal Information

RU.521 (RU320521) is an active, potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) that inhibits the cGAS-mediated signaling with IC50 of 700 nM. RU.521 binds to the cGAS/dsDNA complex with Kd of 36.2 nM.

Storage Conditions

3 years -20°C powder

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