RU.521
Product Specifications
CAS Number
2262452-06-0
Synonyms
RU320521
Target
CGAS
Applications
Autophagy
Smiles
CC1=C (C (=O) N (N1) C2=NC3=C (N2) C=CC (=C3Cl) Cl) C4C5=CC=CC=C5C (=O) O4
Molecular Formula
C19H12Cl2N4O3
Additionnal Information
RU.521 (RU320521) is an active, potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) that inhibits the cGAS-mediated signaling with IC50 of 700 nM. RU.521 binds to the cGAS/dsDNA complex with Kd of 36.2 nM.
Storage Conditions
3 years -20°C powder
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